Therefore, sufferers are always on the lookout for new ways to manage the pain. A lot of migraine sufferers have praised CBD oil for its ability to alleviate migraine pain. While such success with the use of CBD oil is exciting, is there scientific evidence to back up these claims? Or are they just internet hype?
Although the research on the effect of CBD oil on migraine is positive, more research is required as the existing research is limited due to reliance on self-reports, small sample sizes and little or no research on CBD-specific applications. Hopefully, as the legal status of cannabis improves, more detailed studies will be undertaken.
So, What Does Existing Research Say?
A study published in Cannabis and Cannabinoid Research observed some positive effects of oral cannabis. Over a period of six months, 26 subjects who suffered headaches took either ibuprofen or nabilone with oral cannabis. At the end of the study, participants taking the cannabis-nabilone formula reported more improvements in their conditions and better quality of life. However, it’s noteworthy that the researchers studied a combination therapy and not cannabis alone.
In yet another study published in, Pharmacotherapy, researchers reported that out of 48 participants, about 40 percent said they had fewer migraines. The most common side effect noted was drowsiness.
The two studies examined the effect of cannabis - and not pure CBD oil – on migraine pain. More research, as well as clinical trials with human participants, are required to assess the impact of CBD oil on migraines and potential benefits.
Before you seek relief for your migraine with CBD, make sure to contact your primary healthcare provider. They can help advice you on the right dosage and the legal requirements if any.
No one knows the exact cause of ADHD, although genetics has been observed to be a major contributory factor. The current treatment for ADHD consists of the use of medication - classified as stimulants and non-stimulants and behavioral therapy. The drugs are believed to work by altering the level of the neurotransmitter dopamine in the brain. However, they may have some rather unpleasant side effects.
But, Can CBD Oil Treat ADHD?
A basic understanding of how cannabis affects the body through the “Endocannabinoid System” (ECS) is necessary to see how CBD might help relieve ADHD symptoms. The ECS plays a critical role in the regulation of bodily functions such as pain, appetite, inflammation and many others.
Cannabis has over 100 compounds, with the most prominent being THC and CBD. These two compounds along with other cannabinoids interact with the ECS through its receptors known as CB1 and CB2 and alter its functions. For example, CBD can activate serotonin receptors in the body to create an anti-anxiety effect. And THC has been in use as a way to possibly assist against side effects of chemotherapy like loss of appetite and vomiting.
Several studies have indicated the possibility of using cannabis to relieve some of the symptoms of ADHD. A study published in the journal Substance Use & Misuse in 2014, analyzed subtypes of ADHD and cannabis use among 2,811 people. Majority of the participants responded positively to cannabis use showing that cannabis might be useful in reducing at least some presentations of ADHD.
In yet another study presented at the Cannabinoid Conference in 2015, researchers found that cannabis was effective and well-tolerated for adults with ADHD especially those who do not benefit or suffer adverse effects from standard treatments.
Results of a 2012 animal study published in the Journal of Psychopharmacology observed that CBD reduced hyperactivity and regularized “social investigative behavior.” Lab rats were administered with a substance that induces symptoms of ADHD such as shortened attention span; reduced social investigative behavior; and hyperactivity.
After ingesting 3mg per kg dose of CBD, the rats showed significantly reduced hyperactivity and at the same time not only normalized social investigated behavior, but also increased it. However, the rats showed no change in attention span.
In conclusion, Cannabis or CBD oil doesn’t cure ADHD, but it has been found to certainly help alleviate some of the symptoms associated with the condition.
And the problem is prevalent, affecting millions of people across various age ranges. A significant part of the treatment of these back problems involves the relief and management of the associated pain.
The marijuana plant contains many different compounds, with the most important ones being the tetrahydrocannabinol (THC), which is responsible for the “high” effect of marijuana and cannabidiol (CBD), which is the compound associated with the therapeutic effects.
CBD is not psychoactive, and hence less controversial. Marijuana strains can be cultivated to contain no trace of THC. But CBD can be easily extracted, usually in the form of oil and are available in areas where medical marijuana is in use.
In these areas, an increasing number of back pain patients claim they obtained relief from their pain with CDB usage. A good number of patients, seeking alternative therapy for their pain due to the adverse effect their existing medication resorted to CBD oil. While their experiences were overwhelmingly positive, the reports are largely anecdotal and will require further rigorous scientific inquiry.
So, What Makes CBD Capable Of Tackling Spine Pain?
CBD acts directly on the cannabinoid system – the part of the brain responsible for controlling many bodily functions. This compound stimulates the cannabinoid system to reduce inflammation in the body and help reduce pain. Unlike typical pain drugs which are opioids, CBD is neither habit-forming nor does it have adverse side effects. Instead, CBD reduces central nervous effects, according to this research
But can CBD oil help relieve your back pain? Yes, if the reports of dozens of scientific research studies are anything to go by. Here are the summaries of some key research findings:
In a study published in the journal, Current Neuropharmacology, researchers outlined the mechanism by which the cannabinoid system helps in chronic and acute pain management. They observed that the use of CBD may offer some pain relief and suggest it can be an alternative to the use of opioids to prevent central nervous system side effects. They also concluded that the anti-inflammatory actions of CBD are beneficial.
Dr. Kevin P. Hill and others, in a more recent review of the existing literature, agree that although more research is needed, CBD has some pain managing effects. In their report, published in the journal Cannabis And Cannabinoid Research, they concluded, just like in the report above, that CBD is most promising as an alternative to potentially dangerous opioids used in managing pain conditions.
In yet another study, mice with degenerative disc disease responded favorably to high doses of CBD. The researchers discovered reduced damage to spine areas in their test subject. However, they weren't able to determine the exact mechanism.
While further research is being carried out, it’s certain that the evidence is mounting in favor of the use of CBD for relieving spine pain.
So, how much CBD do you need to see results? This is a problem for those in favor of treatment with CBD oil. Because for now, it’s difficult to figure out the right dosage for optimal results. It’s not yet approved by the regulatory bodies. Hence, caution should be taken when taking CBD. Make sure to discuss with your doctor before trying out CBD oil.
Are you worried about how long CBD stays in your body? Maybe you are facing a drug screening at your workplace, and you feel they might test for both CBD and THC?. Whatever your concerns, here is the existing information on the subject.
A study found that patients who took extremely high doses of 700 mg of CBD/day for 6 weeks, didn’t have any trace of CBD in their blood after a week of not dosing. Even at this rare extreme case of dosing, the CBD was entirely out of their system within a week.
So, if you’re a light to moderate user, the time CDB will stay in your system is around 3 - 5 days. This is also applicable to various forms of CBD like topical cream, tinctures, and vapes.
However, these are estimates, and further research is needed to take into consideration other factors and individual differences that might affect the lifespan of CBD in your body.
- cardiovascular disease,
- oral disease,
- kidney disease and more.
- It may help stabilize blood sugars
- Possibly reduce arterial inflammation due to diabetes by acting as an anti-inflammatory.
- It may reduce pain often associated with diabetes due to nerve inflammation or neuropathy.
- It may help improve blood circulation by keeping the blood vessels open.
- Possibly help to reduce blood pressure slowly.
- It may help calm restless leg syndrome which is common with diabetics.
- Possibly help to ease muscle cramping and gastrointestinal disorders by acting as an anti-spasmodic agent
Are these claims just talk or are there some scientific basis to the assertions?Insulin resistance which leads to diabetes is known to be caused by chronic inflammation. Researchers from Israel believe that the anti-inflammatory properties of CBD could reduce this inflammation and improve the body’s metabolism. Additionally, CBD’s anti-inflammatory properties were found to benefit a whole lot of bodily functions which include the immune system, heart function, cell growth, and sugar metabolism. The American Journal of Medicine agrees that cannabis can help control diabetes blood sugar and that users are less likely to be obese. If you suffer from diabetes or are at high risk of developing the disease, you may want to try CBD as an addition to diet changes. But make sure to carry your doctor along.
CBD is a non-psychoactive compound of cannabis. It doesn’t cause a high unlike THC. Luckily, the urine drug test for THC and its derivatives do not cross-react to CBD and other non-psychoactive cannabis compounds.
However, some studies have found that eating hemp foods and ingesting hemp oils can cause a positive result in urine and blood tests in a few cases. Again, regularly consuming large amounts or very high doses of CBD may increase the possibility of testing positive due to cross-reactivity.
In summary, if you are concerned about a positive drug test or you are in the military, a competitive athlete or a first responder that has to undergo strict drug testing, it’s recommended you avoid taking any form of CBD before your test.
Genetic preposition and temperament are some of the many factors that could trigger depression. Some medications can also cause changes in mood in patients.
Depression manifests in several ways individually or in combination:
- Inability to concentrate and remember details
- Insomnia, or excessive sleep
- Experiencing negative emotions: guilt, restlessness, irritability, hopelessness, pessimism or anxiety.
- Loss of interest in everyday activities.
- Loss of appetite or excessive eating.
- Digestive problems and pains and aches
- Suicidal thoughts
Treatment for depression is typically a combination of antidepressant drugs with cognitive behavioral therapy (CBT). Treatment often requires some trial and error to find the right medication. Also, some antidepressant medicine may have quite unpleasant side effects such as weight gain, suicidal tendencies, headaches, nausea, sleep disturbances and more.
It is not surprising then that people are searching for alternatives for depression; and going by the results of dozens of studies, CBD could be the real deal.
Throughout history, marijuana has been used as an antidepressant. But how do cannabis and its compounds relieve depression? Scientists believe that the root cause of depression is an imbalance in the endocannabinoid system. And that is how cannabis and its compounds come in.
The human body has a network of cellular receptors called the endocannabinoid system or ECS. This system is responsible for many bodily functions and consist of cellular receptors and activators
There are two types of receptors – CB1 and CB2. The CB1 receptors are spread throughout the body and are part of the central nervous system, while CB2 receptors are located in the white blood cells, stomach, and peripheral nervous system. The activators are the endocannabinoids which are created by the body but also can be supplemented from outside sources such as cannabis.
The activators and receptors work together to ensure our body runs smoothly. For instance, when your body needs to regulate its temperature, it sends cannabinoids to the CB1 receptors in the hypothalamus with precise instructions on what to do.
So, this is how CBD links with depression: according to researchers at the University of Buffalo, when the body is constantly stressed, it tends to make less of these regulating compounds in our brain which leads to depression.
Cannabinoids which are found in marijuana are a very similar compound to the body’s cannabinoids and can supplement them to increase healing and growth of tissues. Theoretically, cannabinoids should balance and align the endocannabinoid system, to alleviate the symptoms of depression in several ways.
Not only does CBD restore healthy cellular homeostasis, but it also lightens the mood and reduces other symptoms of depression like anxiety, loss of appetite and insomnia.
A variety of experiments performed on animal subjects confirmed that CBD had an anti-anxiety and antidepressant effect. The CBD interacted well with the 5-HT1A neurotransmitter. The 5-HT1A neurotransmitter is a receptor that normally binds to and reuptakes serotonin into the neurons in the brain reducing amounts of free serotonin in the extracellular space. And Serotonin is a neurotransmitter known to play a significant role in the treatment of depression. Therefore compounds which increase serotonin levels like selective serotonin reuptake inhibitors (SSRI’s) or Cannabidiol, are believed to be useful in reducing the effects of depression with little or no side effects.
There is still a whole lot of research to be done, and extensive human trials have not yet been done on CBD treatment for depression. But a lot of users swear by it and if finally, CBD treatment gets the appropriate approvals, it will be a welcome relief for patients who won't have to continue with addictive and expensive anti-depressants.
All in all the legalization of CBD Oil in the United States has now opened the flood gates to full scientific testing of CBD oil’s effectiveness to help alleviate many aliments.
Another factor depends on the potency of the CBD oil or the quality of hemp or marijuana it is derived from. CBD oil in the form of edibles will take much longer to take effect, usually around 60-90 minutes. If it is your first time taking the product, you should see results within half an hour usually. But, if you are an avid CBD oil user, then the turnaround time will be much higher if you are taking the same dose each time. Increasing the dosage will solve most of these problems and allow the CBD oil to work much faster on the body.
Some CBD oils are of higher quality and can sometimes contain trace amounts of THC within the oil which will add to these side effects causing a shortened overdose to occur. Make sure to know where your CBD oil comes from and the chemical compound makeup. Also, be sure to know what your limit is, dosage wise, if you are not an avid user of CBD oil or marijuana. It is important to remember that the sole purpose of using CBD oil is to temporarily relieve any negative symptoms you may have. Abusing the drug will only lead to negative side effects and unwanted stress in the long run which will totally defeat the original purpose of using CBD oil.